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› 4v19

Electron Microscopy
3.4Å resolution

Structure of the large subunit of the mammalian mitoribosome, part 1 of 2

Released:
DOI: 10.2210/pdb4v19/pdb
PDB entry 4v19 coloured by chain, front view.
PDB entry 4v19 coloured by chain, side view.
PDB entry 4v19 coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
The complete structure of the large subunit of the mammalian mitochondrial ribosome.
Greber BJ, Boehringer D, Leibundgut M, Bieri P, Leitner A, Schmitz N, Aebersold R, Ban N
Nature 515 283-6 (2014)
PMID: 25271403
Related structures: EMD-2787

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 32-mer (preferred)
PDBe Complex ID:
PDB-CPX-300305 (preferred)
Entry contents:
28 distinct polypeptide molecules
3 distinct RNA molecules
Macromolecules (31 distinct):
Large ribosomal subunit protein bL27m Chain: 0
Molecule details ›
Chain: 0
Length: 148 amino acids
Theoretical weight: 15.94 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1U0F6 (Residues: 1-148; Coverage: 100%)
Sequence domains: Ribosomal L27 protein
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Large ribosomal subunit protein uL18m Chain: 1
Molecule details ›
Chain: 1
Length: 256 amino acids
Theoretical weight: 30.15 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A0R4J8D5 (Residues: 71-97; Coverage: 17%)
Gene name: MRPL18
Large ribosomal subunit protein uL29m Chain: 2
Large ribosomal subunit protein uL30m Chain: 3
MITORIBOSOMAL PROTEIN BL31M, MRPL55 Chain: 4
Large ribosomal subunit protein bL32m Chain: 5
MITORIBOSOMAL PROTEIN BL33M, MRPL33 Chain: 6
Large ribosomal subunit protein bL34m Chain: 7
Large ribosomal subunit protein bL35m Chain: 8
MITORIBOSOMAL PROTEIN BL36M, MRPL36 Chain: 9
Large ribosomal subunit protein uL2 RNA-binding domain-containing protein Chain: D
MITORIBOSOMAL PROTEIN UL3M, MRPL3 Chain: E
MITORIBOSOMAL PROTEIN UL4M, MRPL4 Chain: F
Large ribosomal subunit protein bL9m Chain: I
Large ribosomal subunit protein uL10m Chain: J
Large ribosomal subunit protein uL11m Chain: K
MITORIBOSOMAL PROTEIN UL13M, MRPL13 Chain: N
Large ribosomal subunit protein uL14m Chain: O
MITORIBOSOMAL PROTEIN UL15M, MRPL15 Chain: P
Large ribosomal subunit protein uL16m Chain: Q
Large ribosomal subunit protein bL17m Chain: R
Large ribosomal subunit protein uL18m Chain: S
Large ribosomal subunit protein bL19m Chain: T
MITORIBOSOMAL PROTEIN BL20M, MRPL20 Chain: U
Large ribosomal subunit protein bL21m Chain: V
MITORIBOSOMAL PROTEIN UL22M, MRPL22 Chain: W
MITORIBOSOMAL PROTEIN UL23M, MRPL23 Chain: X
Large ribosomal subunit protein uL24m Chain: Y
MITORIBOSOMAL 16S RRNA Chain: A
MITORIBOSOMAL CP TRNA Chain: B
tRNA Chains: C, Z

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand MG 169 x MG
1 modified residue:
Ligand P5P 36 x P5P

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.4Å
Relevant EMDB volumes: EMD-2787

Quick links

Citations

50 review citations

Mitochondrial DNA copy number in human disease: the more the better?
Filograna et al. (2021)
49 more

6 mentions without citation

When a common biological role does not imply common disease outcomes: Disparate pathology linked to human mitochondrial aminoacyl-tRNA synthetases.
González-Serrano et al. (2019)
5 more