› 4v4l

Electron Microscopy
6.9Å resolution

Structure of the Drosophila apoptosome

Released:
DOI: 10.2210/pdb4v4l/pdb
PDB entry 4v4l coloured by chain, front view.
PDB entry 4v4l coloured by chain, side view.
PDB entry 4v4l coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure of the Drosophila apoptosome at 6.9 å resolution.
Yuan S, Yu X, Topf M, Dorstyn L, Kumar S, Ludtke SJ, Akey CW
Structure 19 128-40 (2011)
PMID: 21220123
Related structures: EMD-5235

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosome protein Dark Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 1221 amino acids
Theoretical weight: 123.2 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7KLI1 (Residues: 1-583; Coverage: 41%)
Gene names: Apaf-1, Ark, CG6829, Dark, Hac-1, dapaf-1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MG 16 x MG
Ligand DTP 16 x DTP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 6.9Å
Relevant EMDB volumes: EMD-5235
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Apoptosome structure, assembly, and procaspase activation.
Yuan et al. (2013)
13 more

3 mentions without citation

Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death.
Schreiber et al. (2016)
2 more