› 4v58

X-ray diffraction
3.1Å resolution

Crystal structure of fatty acid synthase from thermomyces lanuginosus at 3.1 angstrom resolution.

Released:
DOI: 10.2210/pdb4v58/pdb
PDB entry 4v58 coloured by chain, front view.
PDB entry 4v58 coloured by chain, side view.
PDB entry 4v58 coloured by chain, top view.
Source organism: Thermomyces lanuginosus
Primary publication:
Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.
Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolásek B, Ban N
Science 316 254-61 (2007)
PMID: 17431175

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165263 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
FATTY ACID SYNTHASE ALPHA SUBUNITS Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 1878 amino acids
Theoretical weight: 206.9 KDa
Source organism: Thermomyces lanuginosus
FATTY ACID SYNTHASE BETA SUBUNITS Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 2060 amino acids
Theoretical weight: 229.91 KDa
Source organism: Thermomyces lanuginosus

Ligands and Environments

1 bound ligand:
Ligand FMN 6 x FMN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 216.37Å b: 414.43Å c: 221.51Å
α: 90° β: 111.65° γ: 90°
R-values:
R R work R free
0.29 0.29 0.32

Quick links

Citations

28 review citations

The type I fatty acid and polyketide synthases: a tale of two megasynthases.
Smith et al. (2007)
27 more