› 4w8e

X-ray diffraction
1.79Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 24 36 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 33.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6E0 (Residues: 24-311; Coverage: 65%)
Gene names: MST3, STK24, STK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 3JB 1 x 3JB
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 47.53Å b: 56.49Å c: 61.06Å
α: 90° β: 111.41° γ: 90°
R-values:
R R work R free
0.177 0.175 0.212
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Early synaptic dysfunction in Parkinson's disease: Insights from animal models.
Schirinzi et al. (2016)
21 more

1 mention without citation

An integrated approach towards the development of novel antifungal agents containing thiadiazole: synthesis and a combined similarity search, homology modelling, molecular dynamics and molecular docking study.
Er et al. (2018)