› 4we6

X-ray diffraction
1.9Å resolution

The crystal structure of hemagglutinin HA1 domain from influenza virus A/Perth/142/2007(H3N2)

Released:
DOI: 10.2210/pdb4we6/pdb
PDB entry 4we6 coloured by chain, front view.
PDB entry 4we6 coloured by chain, side view.
PDB entry 4we6 coloured by chain, top view.
Source organism: Influenza A virus (A/Perth/142/2007(H3N2))
Primary publication:
Structure and receptor binding preferences of recombinant human A(H3N2) virus hemagglutinins.
Yang H, Carney PJ, Chang JC, Guo Z, Villanueva JM, Stevens J
Virology 477 18-31 (2015)
PMID: 25617824

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109761 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin Chains: A, B
Molecule details ›
Chains: A, B
Length: 279 amino acids
Theoretical weight: 31.18 KDa
Source organism: Influenza A virus (A/Perth/142/2007(H3N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: B2VNP1 (Residues: 41-314; Coverage: 81%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 4 x NAG
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P2
Unit cell:
a: 42.472Å b: 50.567Å c: 182.256Å
α: 90° β: 90.08° γ: 90°
R-values:
R R work R free
0.171 0.17 0.201
Expression system: Trichoplusia ni

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Citations

11 review citations

Influenza Hemagglutinin and Neuraminidase: Yin⁻Yang Proteins Coevolving to Thwart Immunity.
Kosik et al. (2019)
10 more

1 mention without citation

Structure and receptor binding preferences of recombinant human A(H3N2) virus hemagglutinins.
Yang et al. (2015)