› 4we7

X-ray diffraction
2.5Å resolution

Structure and receptor binding preferences of recombinant human A(H3N2) virus hemagglutinins

Released:
DOI: 10.2210/pdb4we7/pdb
PDB entry 4we7 coloured by chain, front view.
PDB entry 4we7 coloured by chain, side view.
PDB entry 4we7 coloured by chain, top view.
Source organism: Influenza A virus (A/Alberta/026/2012(H3N2))
Primary publication:
Structure and receptor binding preferences of recombinant human A(H3N2) virus hemagglutinins.
Yang H, Carney PJ, Chang JC, Guo Z, Villanueva JM, Stevens J
Virology 477 18-31 (2015)
PMID: 25617824

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197548 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 284 amino acids
Theoretical weight: 31.58 KDa
Source organism: Influenza A virus (A/Alberta/026/2012(H3N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: U3N7S5 (Residues: 57-324; Coverage: 80%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 14 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 48.298Å b: 214.898Å c: 101.807Å
α: 90° β: 103.58° γ: 90°
R-values:
R R work R free
0.22 0.218 0.251
Expression system: Trichoplusia ni

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Citations

11 review citations

Influenza Hemagglutinin and Neuraminidase: Yin⁻Yang Proteins Coevolving to Thwart Immunity.
Kosik et al. (2019)
10 more

2 mentions without citation

Structure and receptor binding preferences of recombinant human A(H3N2) virus hemagglutinins.
Yang et al. (2015)
1 more