› 4we8

X-ray diffraction
2.1Å resolution

The crystal structure of hemagglutinin of influenza virus A/Victoria/361/2011

Released:
DOI: 10.2210/pdb4we8/pdb
PDB entry 4we8 coloured by chain, front view.
PDB entry 4we8 coloured by chain, side view.
PDB entry 4we8 coloured by chain, top view.
Source organism: Influenza A virus (A/Singapore/H2011.447/2011(H3N2))
Primary publication:
Structure and receptor binding preferences of recombinant human A(H3N2) virus hemagglutinins.
Yang H, Carney PJ, Chang JC, Guo Z, Villanueva JM, Stevens J
Virology 477 18-31 (2015)
PMID: 25617824

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195817 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 515 amino acids
Theoretical weight: 57.84 KDa
Source organism: Influenza A virus (A/Singapore/H2011.447/2011(H3N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: R9U684 (Residues: 17-519; Coverage: 89%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 7 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R32
Unit cell:
a: 100.911Å b: 100.911Å c: 383.361Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.19 0.227
Expression system: Trichoplusia ni

Quick links

Citations

11 review citations

Influenza Hemagglutinin and Neuraminidase: Yin⁻Yang Proteins Coevolving to Thwart Immunity.
Kosik et al. (2019)
10 more

15 mentions without citation

Biosensor-based epitope mapping of antibodies targeting the hemagglutinin and neuraminidase of influenza A virus.
Guo et al. (2018)
14 more