› 4wip

X-ray diffraction
2.69Å resolution

DIX domain of human Dvl2

Released:
DOI: 10.2210/pdb4wip/pdb
PDB entry 4wip coloured by chain, front view.
PDB entry 4wip coloured by chain, side view.
PDB entry 4wip coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization.
Madrzak J, Fiedler M, Johnson CM, Ewan R, Knebel A, Bienz M, Chin JW
Nat Commun 6 6718 (2015)
PMID: 25907794

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127035 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Segment polarity protein dishevelled homolog DVL-2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 97 amino acids
Theoretical weight: 10.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14641 (Residues: 11-106; Coverage: 13%)
Gene name: DVL2
Sequence domains: DIX domain
Structure domains: Ribosomal Protein L25; Chain P

Ligands and Environments

1 bound ligand:
Ligand 1PE 3 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 56.3Å b: 84.82Å c: 98.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.248
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.
Mlodzik M. (2016)
6 more

9 mentions without citation

Wnt signaling in triple-negative breast cancer.
Pohl et al. (2017)
8 more