› 4wja

X-ray diffraction
2.6Å resolution

Crystal Structure of PAXX

Released:
DOI: 10.2210/pdb4wja/pdb
PDB entry 4wja coloured by chain, front view.
PDB entry 4wja coloured by chain, side view.
PDB entry 4wja coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D
Nat Commun 6 6233 (2015)
PMID: 25670504

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189734 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein PAXX Chains: A, B
Molecule details ›
Chains: A, B
Length: 161 amino acids
Theoretical weight: 17.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q9BUH6 (Residues: 1-145; Coverage: 71%)
Gene names: C9orf142, PAXX, XLS
Sequence domains: PAXX, PAralog of XRCC4 and XLF, also called C9orf142

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P6522
Unit cell:
a: 91.825Å b: 91.825Å c: 152.468Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.245 0.266
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

30 review citations

Non-homologous DNA end joining and alternative pathways to double-strand break repair.
Chang et al. (2017)
29 more

1 mention without citation

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Xing et al. (2015)