› 4wn0

X-ray diffraction
2.2Å resolution

Xenopus laevis embryonic epidermal lectin in complex with glycerol phosphate

Released:
DOI: 10.2210/pdb4wn0/pdb
PDB entry 4wn0 coloured by chain, front view.
PDB entry 4wn0 coloured by chain, side view.
PDB entry 4wn0 coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.
Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT
J Biol Chem 291 5596-5610 (2016)
PMID: 26755729

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177744 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Intelectin-1 Chain: A
Molecule details ›
Chain: A
Length: 289 amino acids
Theoretical weight: 31.65 KDa
Source organism: Xenopus laevis
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q5PPM0 (Residues: 51-339; Coverage: 90%)
Gene name: itln1
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain

Ligands and Environments

4 bound ligands:
Ligand CA 3 x CA
Ligand PO4 1 x PO4
Ligand 1PE 4 x 1PE
Ligand G3P 1 x G3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P6
Unit cell:
a: 124.628Å b: 124.628Å c: 55.585Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.152 0.152 0.169
Expression system: Trichoplusia ni

Quick links

Citations

5 review citations

Recognition of microbial glycans by soluble human lectins.
Wesener et al. (2017)
4 more

6 mentions without citation

Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.
Wangkanont et al. (2016)
5 more