4wpf

X-ray diffraction
2.2Å resolution

Crystal structure of RORc in complex with a phenyl sulfonamide agonist

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-156327 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor ROR-gamma Chains: A, D
Molecule details ›
Chains: A, D
Length: 264 amino acids
Theoretical weight: 30.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51449 (Residues: 262-509; Coverage: 48%)
Gene names: NR1F3, RORC, RORG, RZRG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
RHKILHRLLQEGSPS Chains: B, E
Molecule details ›
Chains: B, E
Length: 11 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P41
Unit cell:
a: 61.692Å b: 61.692Å c: 155.232Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.175 0.227
Expression systems:
  • Escherichia coli
  • Not provided