› 4wsu

X-ray diffraction
2.7Å resolution

The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN

Released:
DOI: 10.2210/pdb4wsu/pdb
Model geometry
Fit model/data
PDB entry 4wsu coloured by chain, front view.
PDB entry 4wsu coloured by chain, side view.
PDB entry 4wsu coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes.
Yang H, Carney PJ, Chang JC, Villanueva JM, Stevens J
J Virol 89 4612-23 (2015)
PMID: 25673707

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102260 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Hemagglutinin Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 334 amino acids
Theoretical weight: 37.43 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A0J9X246 (Residues: 1-334; Coverage: 100%)
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 181 amino acids
Theoretical weight: 20.72 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A0J9X245 (Residues: 1-181; Coverage: 100%)
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL
Carbohydrate polymer
2 bound ligands:
Ligand NAG 9 x NAG
Ligand SIA 2 x SIA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 186.978Å b: 100.08Å c: 135.239Å
α: 90° β: 126.04° γ: 90°
R-values:
R R work R free
0.214 0.212 0.244
Expression system: Trichoplusia ni

Quick links

Citations

7 review citations

Structural insights into the design of novel anti-influenza therapies.
Wu et al. (2018)
6 more

1 mention without citation

Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes.
Yang et al. (2015)