› 4wsx

X-ray diffraction
2.7Å resolution

The crystal structure of hemagglutinin from A/Jiangxi-Donghu/346/2013 influenza virus

Released:
DOI: 10.2210/pdb4wsx/pdb
PDB entry 4wsx coloured by chain, front view.
PDB entry 4wsx coloured by chain, side view.
PDB entry 4wsx coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes.
Yang H, Carney PJ, Chang JC, Villanueva JM, Stevens J
J Virol 89 4612-23 (2015)
PMID: 25673707

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102264 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemagglutinin Chains: A, C, E, G, I, K, M, O, Q, S, U, W
Molecule details ›
Chains: A, C, E, G, I, K, M, O, Q, S, U, W
Length: 327 amino acids
Theoretical weight: 35.74 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A0J9X252 (Residues: 1-327; Coverage: 100%)
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 chain Chains: B, D, F, H, J, L, N, P, R, T, V, X
Molecule details ›
Chains: B, D, F, H, J, L, N, P, R, T, V, X
Length: 174 amino acids
Theoretical weight: 19.99 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A0J9X253 (Residues: 1-174; Coverage: 100%)
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

1 bound ligand:
Ligand NAG 24 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 217.395Å b: 217.612Å c: 146.266Å
α: 90° β: 89.98° γ: 90°
R-values:
R R work R free
0.244 0.243 0.266
Expression system: Trichoplusia ni

Quick links

Citations

7 review citations

Structural insights into the design of novel anti-influenza therapies.
Wu et al. (2018)
6 more

2 mentions without citation

Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes.
Yang et al. (2015)
1 more