› 4x05

X-ray diffraction
1.98Å resolution

Crystal structure of P domain from norovirus strain Farmington Hills 2004 in complex with HBGA type B (triglycan)

Released:
DOI: 10.2210/pdb4x05/pdb
Model geometry
Fit model/data
PDB entry 4x05 coloured by chain, front view.
PDB entry 4x05 coloured by chain, side view.
PDB entry 4x05 coloured by chain, top view.
Source organism: Norovirus Hu/GII.4/Farmington Hills/2004/USA
Primary publication:
Human noroviruses' fondness for histo-blood group antigens.
Singh BK, Leuthold MM, Hansman GS
J Virol 89 2024-40 (2015)
PMID: 25428879

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Major capsid protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 307 amino acids
Theoretical weight: 33.79 KDa
Source organism: Norovirus Hu/GII.4/Farmington Hills/2004/USA
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: R4I4P2 (Residues: 225-530; Coverage: 57%)
Sequence domains: Calicivirus coat protein C-terminal
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLA, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 175.11Å b: 89.54Å c: 106.73Å
α: 90° β: 127.55° γ: 90°
R-values:
R R work R free
0.165 0.163 0.203
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Human Milk Oligosaccharides as Promising Antivirals.
Morozov et al. (2018)
15 more

3 mentions without citation

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families.
Pascual Alonso et al. (2023)
2 more