› 4x11

X-ray diffraction
2.3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161035 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein VP1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 272 amino acids
Theoretical weight: 30.03 KDa
Source organism: JC polyomavirus type 3
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P90498 (Residues: 23-290; Coverage: 76%)
Gene name: VP1
Sequence domains: Polyomavirus coat protein
Structure domains: Capsid protein VP1,Polyomavirus

Ligands and Environments

4 bound ligands:
Ligand SIA 3 x SIA
Ligand EDO 14 x EDO
Ligand GOL 4 x GOL
Ligand K 6 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 150.14Å b: 96.1Å c: 127.95Å
α: 90° β: 110.18° γ: 90°
R-values:
R R work R free
0.163 0.161 0.201
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Virus-Receptor Interactions: The Key to Cellular Invasion.
Maginnis MS. (2018)
13 more

4 mentions without citation

The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity.
Ströh et al. (2015)
3 more