› 4x5k

X-ray diffraction
2.49Å resolution

Human NAA50 complex with coenzyme A and an acetylated peptide

Released:
DOI: 10.2210/pdb4x5k/pdb
PDB entry 4x5k coloured by chain, front view.
PDB entry 4x5k coloured by chain, side view.
PDB entry 4x5k coloured by chain, top view.
Source organisms:
Entry authors: Reddi R, Addlagatta A

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + an N-terminal-L-methionyl-L-alanyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165346 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N-alpha-acetyltransferase 50 Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9GZZ1 (Residues: 1-169; Coverage: 100%)
Gene names: MAK3, NAA50, NAT13, NAT5
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase
ACE-MMAS Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 465 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments


Cofactor: Ligand COA 1 x COA
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 44.626Å b: 53.193Å c: 67.586Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.255
Expression systems:
  • Escherichia coli BL21
  • Not provided

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