› 4x8x

X-ray diffraction
2.5Å resolution

Crystal structure of Dscam1 isoform 1.9, N-terminal four Ig domains

Released:
DOI: 10.2210/pdb4x8x/pdb
PDB entry 4x8x coloured by chain, front view.
PDB entry 4x8x coloured by chain, side view.
PDB entry 4x8x coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition.
Li SA, Cheng L, Yu Y, Wang JH, Chen Q
Sci Adv 2 e1501118 (2016)
PMID: 27386517

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192416 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Cell adhesion molecule Dscam1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 394 amino acids
Theoretical weight: 43.58 KDa
Source organism: Drosophila melanogaster
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q0E9H9 (Residues: 34-258, 259-424; Coverage: 20%)
Gene names: CG17800, Dscam, Dscam1, p270
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 92.858Å b: 59.806Å c: 93.604Å
α: 90° β: 92.84° γ: 90°
R-values:
R R work R free
0.212 0.211 0.237
Expression system: Trichoplusia ni

Quick links

Citations

2 review citations

Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly.
Mountoufaris et al. (2018)
1 more