› 4xbi

X-ray diffraction
2.01Å resolution

Structure Of A Malarial Protein Involved in Proteostasis

Released:
DOI: 10.2210/pdb4xbi/pdb
PDB entry 4xbi coloured by chain, front view.
PDB entry 4xbi coloured by chain, side view.
PDB entry 4xbi coloured by chain, top view.
Source organisms:
Primary publication:
Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design.
AhYoung AP, Koehl A, Cascio D, Egea PF
Protein Sci 24 1508-20 (2015)
PMID: 26130467

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154523 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Clp R domain-containing protein; Green fluorescent protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 381 amino acids
Theoretical weight: 43.28 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IB03 (Residues: 152-298; Coverage: 14%)
  • Canonical: P42212 (Residues: 2-230; Coverage: 96%)
Gene names: GFP, PF3D7_0816600
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
1 modified residue:
Ligand CRO 2 x CRO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P65
Unit cell:
a: 127.53Å b: 127.53Å c: 92.57Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.168 0.167 0.202
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Transport mechanisms at the malaria parasite-host cell interface.
Beck et al. (2021)
7 more

2 mentions without citation

Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design.
AhYoung et al. (2015)
1 more