› 4xbq

X-ray diffraction
2.23Å resolution

Crystal Structure of Human Galectin-7 in Complex with Type 1 N-acetyllactosamine

Released:
DOI: 10.2210/pdb4xbq/pdb
PDB entry 4xbq coloured by chain, front view.
PDB entry 4xbq coloured by chain, side view.
PDB entry 4xbq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for GalĪ²1-3/4GlcNAc.
Hsieh TJ, Lin HY, Tu Z, Huang BS, Wu SC, Lin CH
PLoS One 10 e0125946 (2015)
PMID: 25945972

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155678 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 155 amino acids
Theoretical weight: 17.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P47929 (Residues: 1-136; Coverage: 100%)
Gene names: LGALS7, LGALS7B, PIG1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P212121
Unit cell:
a: 30.085Å b: 55.411Å c: 136.497Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.196 0.224
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis.
Sindrewicz et al. (2016)
3 more

2 mentions without citation

Galectin-7 in Epithelial Homeostasis and Carcinomas.
Advedissian et al. (2017)
1 more