› 4xhs

X-ray diffraction
1.7Å resolution

Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction

Released:
DOI: 10.2210/pdb4xhs/pdb
PDB entry 4xhs coloured by chain, front view.
PDB entry 4xhs coloured by chain, side view.
PDB entry 4xhs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction.
Jin T, Huang M, Jiang J, Smith P, Xiao TS
PLoS One 13 e0190547 (2018)
PMID: 29293680

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Maltose/maltodextrin-binding periplasmic protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 480 amino acids
Theoretical weight: 52.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
Gene names: JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
2 bound ligands:
Ligand FMT 4 x FMT
Ligand NA 7 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Unit cell:
a: 52.72Å b: 103.62Å c: 186.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.16 0.19
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections.
Babamale et al. (2021)
1 more

4 mentions without citation

Assembly of platforms for signal transduction in the new era: dimerization, helical filament assembly, and beyond.
Ha et al. (2020)
3 more