› 4xhz

X-ray diffraction
2.8Å resolution

Crystal Structure of Human Protocadherin-15 EC8-10

Released:
DOI: 10.2210/pdb4xhz/pdb
PDB entry 4xhz coloured by chain, front view.
PDB entry 4xhz coloured by chain, side view.
PDB entry 4xhz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An elastic element in the protocadherin-15 tip link of the inner ear.
Araya-Secchi R, Neel BL, Sotomayor M
Nat Commun 7 13458 (2016)
PMID: 27857071

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188706 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protocadherin-15 Chain: A
Molecule details ›
Chain: A
Length: 338 amino acids
Theoretical weight: 37.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96QU1 (Residues: 816-1144; Coverage: 17%)
Gene names: PCDH15, USH1F
Sequence domains: Cadherin domain

Ligands and Environments

2 bound ligands:
Ligand CA 3 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6322
Unit cell:
a: 157.929Å b: 157.929Å c: 142.898Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.171 0.17 0.2
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

Evolution and diversity of cadherins and catenins.
Gul et al. (2017)
6 more

4 mentions without citation

Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance.
Jaiganesh et al. (2018)
3 more