› 4xl8

X-ray diffraction
1.65Å resolution

Crystal Structure of Human Adenovirus 52 Short Fiber Knob in Complex with 2-O-Methyl-5-N-Acetylneuraminic Acid

Released:
DOI: 10.2210/pdb4xl8/pdb
PDB entry 4xl8 coloured by chain, front view.
PDB entry 4xl8 coloured by chain, side view.
PDB entry 4xl8 coloured by chain, top view.
Source organism: Human adenovirus 52
Primary publication:
Human adenovirus 52 uses sialic acid-containing glycoproteins and the coxsackie and adenovirus receptor for binding to target cells.
Lenman A, Liaci AM, Liu Y, Årdahl C, Rajan A, Nilsson E, Bradford W, Kaeshammer L, Jones MS, Frängsmyr L, Feizi T, Stehle T, Arnberg N
PLoS Pathog 11 e1004657 (2015)
PMID: 25674795

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106130 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenoviral fibre protein knob domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 209 amino acids
Theoretical weight: 22.42 KDa
Source organism: Human adenovirus 52
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0MK70 (Residues: 183-363; Coverage: 50%)
Sequence domains: Adenoviral fibre protein (knob domain)
Structure domains: Adenovirus pIV-related, attachment domain

Ligands and Environments

7 bound ligands:
Ligand MNA 2 x MNA
Ligand GOL 1 x GOL
Ligand TAM 1 x TAM
Ligand GLU 1 x GLU
Ligand ALA 1 x ALA
Ligand MPD 1 x MPD
Ligand MRD 1 x MRD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 63.77Å b: 81.61Å c: 92.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.152 0.151 0.174
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

18 review citations

Tight Junctions Go Viral!
Torres-Flores et al. (2015)
17 more

2 mentions without citation

Adenovirus Structure: What Is New?
Gallardo et al. (2021)
1 more