› 4xq7

X-ray diffraction
1.6Å resolution

The crystal structure of the OAS-like domain (OLD) of human OASL

Released:
DOI: 10.2210/pdb4xq7/pdb
PDB entry 4xq7 coloured by chain, front view.
PDB entry 4xq7 coloured by chain, side view.
PDB entry 4xq7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling.
Ibsen MS, Gad HH, Andersen LL, Hornung V, Julkunen I, Sarkar SN, Hartmann R
Nucleic Acids Res 43 5236-48 (2015)
PMID: 25925578

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2'-5'-oligoadenylate synthase-like protein Chain: A
Molecule details ›
Chain: A
Length: 359 amino acids
Theoretical weight: 41.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15646 (Residues: 1-350; Coverage: 68%)
Gene names: OASL, TRIP14
Sequence domains: 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CME 1 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P21
Unit cell:
a: 54.8Å b: 57.62Å c: 64.79Å
α: 90° β: 99.44° γ: 90°
R-values:
R R work R free
0.168 0.167 0.193
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5.
Brisse et al. (2019)
10 more

4 mentions without citation

Functional Interfaces, Biological Pathways, and Regulations of Interferon-Related DNA Damage Resistance Signature (IRDS) Genes.
Padariya et al. (2021)
3 more