› 4xrq

X-ray diffraction
1.95Å resolution

Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) in complex with PF-3450074

Released:
DOI: 10.2210/pdb4xrq/pdb
PDB entry 4xrq coloured by chain, front view.
PDB entry 4xrq coloured by chain, side view.
PDB entry 4xrq coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
Zhou J, Price AJ, Halambage UD, James LC, Aiken C
J Virol 89 9068-79 (2015)
PMID: 26109731

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.47 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1B0 1 x 1B0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P6
Unit cell:
a: 90.35Å b: 90.35Å c: 56.93Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.221
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Capsid-Dependent Host Factors in HIV-1 Infection.
Yamashita et al. (2017)
7 more

2 mentions without citation

The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter.
AlBurtamani et al. (2021)
1 more