› 4y0l

X-ray diffraction
2.4Å resolution

Mycobacterial membrane protein MmpL11D2

Released:
DOI: 10.2210/pdb4y0l/pdb
PDB entry 4y0l coloured by chain, front view.
PDB entry 4y0l coloured by chain, side view.
PDB entry 4y0l coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis.
Chim N, Torres R, Liu Y, Capri J, Batot G, Whitelegge JP, Goulding CW
Chem Biol 22 1098-107 (2015)
PMID: 26278184

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heme uptake protein MmpL11 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 9.18 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WJT9 (Residues: 424-511; Coverage: 9%)
Gene names: MTV033.10c, Rv0202c, mmpL11

Ligands and Environments

2 bound ligands:
Ligand IOD 9 x IOD
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2221
Unit cell:
a: 65.6Å b: 91.73Å c: 32.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.208 0.254
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments.
Viljoen et al. (2017)
7 more

5 mentions without citation

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.
Alav et al. (2021)
4 more