Function and Biology Details
Biochemical function:
- not assigned
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
Insulin complex (preferred)
PDBe Complex ID:
PDB-CPX-229761 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (7 distinct):
HLA class II histocompatibility antigen, DR alpha chain
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Structure domains:
Length: 189 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P01903 (Residues: 26-206; Coverage: 79%)
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1 beta chain
Molecule details ›
Chain: B
Length: 200 amino acids
Theoretical weight: 23.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Structure domains:
Length: 200 amino acids
Theoretical weight: 23.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Sequence domains:
Structure domains:
Insulin A chain
Molecule details ›
Chain: C
Length: 16 amino acids
Theoretical weight: 1.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 16 amino acids
Theoretical weight: 1.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P01308 (Residues: 75-90; Coverage: 19%)
Ligands and Environments
1 bound ligand:
No modified residues
Experiments and Validation Details
X-ray source:
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup:
I222
Expression systems:
- Homo sapiens
- Not provided
- Escherichia coli BL21
