› 4y5y

X-ray diffraction
2.85Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-229910 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
diabody 330 VH domain Chains: A, D
Molecule details ›
Chains: A, D
Length: 130 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Structure domains: Immunoglobulins
diabody 330 VL domain Chains: B, E
Molecule details ›
Chains: B, E
Length: 117 amino acids
Theoretical weight: 12.02 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Structure domains: Immunoglobulins
Erythropoietin receptor Chains: C, F
Molecule details ›
Chains: C, F
Length: 229 amino acids
Theoretical weight: 25.21 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19235 (Residues: 32-249; Coverage: 45%)
Gene name: EPOR
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
1 modified residue:
Ligand MLY 10 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Unit cell:
a: 78.141Å b: 95.799Å c: 144.972Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.241
Expression system: Trichoplusia ni

Quick links

Citations

25 review citations

Conformational Basis of G Protein-Coupled Receptor Signaling Versatility.
Wingler et al. (2020)
24 more

6 mentions without citation

Emerging principles of cytokine pharmacology and therapeutics.
Saxton et al. (2023)
5 more