4y7r

X-ray diffraction
1.9Å resolution

Crystal structure of WDR5 in complex with MYC MbIIIb peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-133948 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 34.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 22-334; Coverage: 94%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Myc proto-oncogene protein Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 889 Da
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P01106 (Residues: 275-282; Coverage: 2%)
Gene names: BHLHE39, MYC

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P21212
Unit cell:
a: 80.762Å b: 87.177Å c: 44.914Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.159 0.188
Expression systems:
  • Escherichia coli
  • Not provided