› 4y8a

X-ray diffraction
1.83Å resolution

Crystal Structure of the N-terminal domain of CEACAM6

Released:
DOI: 10.2210/pdb4y8a/pdb
PDB entry 4y8a coloured by chain, front view.
PDB entry 4y8a coloured by chain, side view.
PDB entry 4y8a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Diverse oligomeric states of CEACAM IgV domains.
Bonsor DA, Günther S, Beadenkopf R, Beckett D, Sundberg EJ
Proc Natl Acad Sci U S A 112 13561-6 (2015)
PMID: 26483485

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154053 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carcinoembryonic antigen-related cell adhesion molecule 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 11.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P40199 (Residues: 34-141; Coverage: 35%)
Gene names: CEACAM6, NCA
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand ZN 7 x ZN
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P63
Unit cell:
a: 96.66Å b: 96.66Å c: 54.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.167 0.195
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches.
Lee et al. (2017)
3 more

4 mentions without citation

Interactions of pathogenic Escherichia coli with CEACAMs.
Sheikh et al. (2023)
3 more