› 4yb9

X-ray diffraction
3.2Å resolution

Crystal structure of the Bovine Fructose transporter GLUT5 in an open inward-facing conformation

Released:
DOI: 10.2210/pdb4yb9/pdb
PDB entry 4yb9 coloured by chain, front view.
PDB entry 4yb9 coloured by chain, side view.
PDB entry 4yb9 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structure and mechanism of the mammalian fructose transporter GLUT5.
Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D
Nature 526 397-401 (2015)
PMID: 26416735

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 2, facilitated glucose transporter member 5 Chain: D
Molecule details ›
Chain: D
Length: 479 amino acids
Theoretical weight: 52.95 KDa
Source organism: Bos taurus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P58353 (Residues: 1-473; Coverage: 94%)
Gene names: GLUT5, SLC2A5
Sequence domains: Sugar (and other) transporter
Structure domains: MFS general substrate transporter like domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 74.61Å b: 112.15Å c: 139.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.237 0.258
Expression system: Saccharomyces cerevisiae

Quick links

Citations

29 review citations

Shared Molecular Mechanisms of Membrane Transporters.
Drew et al. (2016)
28 more

27 mentions without citation

GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters.
Deng et al. (2016)
26 more