› 4ycl

X-ray diffraction
3.25Å resolution

Crystal structure of the SR CA2+-ATPASE with bound CPA

Released:
DOI: 10.2210/pdb4ycl/pdb
PDB entry 4ycl coloured by chain, front view.
PDB entry 4ycl coloured by chain, side view.
PDB entry 4ycl coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors.
Takahashi M, Kondou Y, Toyoshima C
Proc Natl Acad Sci U S A 104 5800-5 (2007)
PMID: 17389383

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

3 bound ligands:
Ligand K 1 x K
Ligand MG 1 x MG
Ligand CZA 1 x CZA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 63.039Å b: 96.029Å c: 155.418Å
α: 90° β: 95.09° γ: 90°
R-values:
R R work R free
0.199 0.197 0.237

Quick links

Citations

13 review citations

P-type ATPases.
Palmgren et al. (2011)
12 more

1 mention without citation

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.
Aguayo-Ortiz et al. (2020)