› 4ydj

X-ray diffraction
2.31Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230342 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein gp160 Chains: G, I
Molecule details ›
Chains: G, I
Length: 353 amino acids
Theoretical weight: 39.21 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0ED31 (Residues: 43-122, 201-303, 325-486; Coverage: 40%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
HEAVY CHAIN OF ANTIBODY 44-VRC13.01 Chains: A, H
Molecule details ›
Chains: A, H
Length: 238 amino acids
Theoretical weight: 25.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
LIGHT CHAIN OF ANTIBODY 44-VRC13.01 Chains: B, L
Molecule details ›
Chains: B, L
Length: 206 amino acids
Theoretical weight: 22.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

6 bound ligands:
Ligand NAG 22 x NAG
Ligand IPA 3 x IPA
Ligand BU3 4 x BU3
Ligand NA 1 x NA
Ligand PEG 3 x PEG
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21212
Unit cell:
a: 293.796Å b: 67.053Å c: 93.638Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.223 0.25
Expression system: Homo sapiens

Quick links

Citations

62 review citations

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.
Burton et al. (2016)
61 more

5 mentions without citation

VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design.
Chen et al. (2019)
4 more