› 4ydk

X-ray diffraction
2.05Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230343 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 353 amino acids
Theoretical weight: 39.21 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0ED31 (Residues: 43-122, 201-303, 325-486; Coverage: 40%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
HEAVY CHAIN OF ANTIBODY C38-VRC16.01 Chain: H
Molecule details ›
Chain: H
Length: 234 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
LIGHT CHAIN OF ANTIBODY C38-VRC16.01 Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

4 bound ligands:
Ligand NAG 10 x NAG
Ligand PEG 7 x PEG
Ligand GOL 13 x GOL
Ligand NHE 1 x NHE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 125.836Å b: 109.686Å c: 100.063Å
α: 90° β: 126.26° γ: 90°
R-values:
R R work R free
0.168 0.166 0.206
Expression system: Homo sapiens

Quick links

Citations

63 review citations

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.
Burton et al. (2016)
62 more

7 mentions without citation

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Zhou et al. (2015)
6 more