› 4ydv

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134625 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Transmembrane protein gp41 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 13 amino acids
Theoretical weight: 1.19 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 596-606; Coverage: 1%)
Gene name: env
Immunoglobulin kappa constant Chains: A, L
Molecule details ›
Chains: A, L
Length: 265 amino acids
Theoretical weight: 29.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: B, H
Molecule details ›
Chains: B, H
Length: 252 amino acids
Theoretical weight: 27.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 5-119, 120-241; Coverage: 50%)
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 73.434Å b: 76.281Å c: 127.627Å
α: 90° β: 98.06° γ: 90°
R-values:
R R work R free
0.191 0.189 0.223
Expression systems:
  • Not provided
  • Homo sapiens

Quick links

Citations

26 review citations

Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection.
Ferrari et al. (2016)
25 more

4 mentions without citation

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.
Santra et al. (2015)
3 more