› 4yet

X-ray diffraction
1.75Å resolution

X-ray crystal structure of superoxide dismutase from Babesia bovis solved by Sulfur SAD

Released:
DOI: 10.2210/pdb4yet/pdb
PDB entry 4yet coloured by chain, front view.
PDB entry 4yet coloured by chain, side view.
PDB entry 4yet coloured by chain, top view.
Source organism: Babesia bovis
Primary publication:
Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.
Phan IQ, Davies DR, Moretti NS, Shanmugam D, Cestari I, Anupama A, Fairman JW, Edwards TE, Stuart K, Schenkman S, Myler PJ
Acta Crystallogr F Struct Biol Commun 71 615-21 (2015)
PMID: 25961325

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127549 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase Chains: A, B
Molecule details ›
Chains: A, B
Length: 203 amino acids
Theoretical weight: 22.9 KDa
Source organism: Babesia bovis
Expression system: Escherichia coli
UniProt:
  • Canonical: O15904 (Residues: 1-199; Coverage: 100%)
Gene name: Fe-SOD
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand FE 2 x FE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 55.75Å b: 69.09Å c: 114.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 0.143 0.176
Expression system: Escherichia coli

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Citations

4 review citations

Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in Trypanosoma cruzi.
Mesías et al. (2019)
3 more

1 mention without citation

Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.
Phan et al. (2015)