› 4ykc

X-ray diffraction
2.7Å resolution

Crystal structure of cerebral cavernous malformation 2 C-terminal adaptor domain

Released:
DOI: 10.2210/pdb4ykc/pdb
PDB entry 4ykc coloured by chain, front view.
PDB entry 4ykc coloured by chain, side view.
PDB entry 4ykc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3.
Wang X, Hou Y, Deng K, Zhang Y, Wang DC, Ding J
Structure 23 1087-96 (2015)
PMID: 25982527

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189709 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cerebral cavernous malformations 2 protein Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 18.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BSQ5 (Residues: 290-444; Coverage: 35%)
Gene names: C7orf22, CCM2, PP10187
Sequence domains: Cerebral cavernous malformation protein, harmonin-homology
Structure domains: Paired amphipathic helix 2 (pah2 repeat)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: I4122
Unit cell:
a: 113.3Å b: 113.3Å c: 102.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.219 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Cerebral Cavernous Malformations: Review of the Genetic and Protein-Protein Interactions Resulting in Disease Pathogenesis.
Baranoski et al. (2016)
4 more

1 mention without citation

Structure and Membrane Targeting of the PDZD7 Harmonin Homology Domain (HHD) Associated With Hearing Loss.
Lin et al. (2021)