› 4ym1

X-ray diffraction
2Å resolution

Crystal structure of the human galectin-4 C-terminal carbohydrate recognition domain in complex with 2'-fucosyllactose

Released:
DOI: 10.2210/pdb4ym1/pdb
PDB entry 4ym1 coloured by chain, front view.
PDB entry 4ym1 coloured by chain, side view.
PDB entry 4ym1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens.
Bum-Erdene K, Leffler H, Nilsson UJ, Blanchard H
FEBS J 282 3348-67 (2015)
PMID: 26077389

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 153 amino acids
Theoretical weight: 16.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56470 (Residues: 171-323; Coverage: 47%)
Gene name: LGALS4
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL, FUC
Carbohydrate polymer
1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 45.292Å b: 129.962Å c: 45.207Å
α: 90° β: 96.96° γ: 90°
R-values:
R R work R free
0.165 0.163 0.213
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives.
Wdowiak et al. (2018)
4 more

2 mentions without citation

Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens.
Bum-Erdene et al. (2015)
1 more