› 4ym3

X-ray diffraction
1.89Å resolution

Crystal structure of the human galectin-4 C-terminal carbohydrate recognition domain in complex with lactose

Released:
DOI: 10.2210/pdb4ym3/pdb
PDB entry 4ym3 coloured by chain, front view.
PDB entry 4ym3 coloured by chain, side view.
PDB entry 4ym3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens.
Bum-Erdene K, Leffler H, Nilsson UJ, Blanchard H
FEBS J 282 3348-67 (2015)
PMID: 26077389

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 153 amino acids
Theoretical weight: 16.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56470 (Residues: 171-323; Coverage: 47%)
Gene name: LGALS4
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 45.533Å b: 130.185Å c: 45.465Å
α: 90° β: 96.91° γ: 90°
R-values:
R R work R free
0.169 0.167 0.196
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives.
Wdowiak et al. (2018)
4 more

4 mentions without citation

Glycomimetics for the inhibition and modulation of lectins.
Leusmann et al. (2023)
3 more