Function and Biology Details
Reactions catalysed:
DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) +diphosphate.
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA polymerase family X
- DNA polymerase family X, beta-like
- Nucleotidyltransferase superfamily
- Helix-hairpin-helix DNA-binding motif, class 1
- DNA-directed DNA polymerase X
- DNA polymerase lambda lyase domain superfamily
- DNA polymerase, thumb domain superfamily
- DNA polymerase beta, thumb domain
4 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
DNA polymerase beta and DNA (preferred)
PDBe Complex ID:
PDB-CPX-118330 (preferred)
Entry contents:
1 distinct polypeptide molecule
3 distinct DNA molecules
3 distinct DNA molecules
Macromolecules (4 distinct):
DNA polymerase beta
Molecule details ›
Chain: A
Length: 335 amino acids
Theoretical weight: 38.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 335 amino acids
Theoretical weight: 38.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P06746 (Residues: 1-335; Coverage: 100%)
Sequence domains:
- Helix-hairpin-helix domain
- Fingers domain of DNA polymerase lambda
- DNA polymerase beta palm
- DNA polymerase beta thumb
