› 4z11

X-ray diffraction
2.5Å resolution

Latent aurone synthase (polyphenol oxidase) from natural source

Released:
DOI: 10.2210/pdb4z11/pdb
PDB entry 4z11 coloured by chain, front view.
PDB entry 4z11 coloured by chain, side view.
PDB entry 4z11 coloured by chain, top view.
Source organism: Coreopsis grandiflora
Primary publication:
Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases.
Molitor C, Mauracher SG, Rompel A
Proc Natl Acad Sci U S A 113 E1806-15 (2016)
PMID: 26976571

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100470 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosinase copper-binding domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 517 amino acids
Theoretical weight: 59.01 KDa
Source organism: Coreopsis grandiflora
UniProt:
  • Canonical: A0A075DN54 (Residues: 86-602; Coverage: 86%)
Sequence domains:
Structure domains: Di-copper center containing domain from catechol oxidase

Ligands and Environments

1 bound ligand:
Ligand CU 8 x CU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 62.57Å b: 174.1Å c: 102.54Å
α: 90° β: 105.27° γ: 90°
R-values:
R R work R free
0.186 0.183 0.234

Quick links

Citations

13 review citations

Chalcone: A Privileged Structure in Medicinal Chemistry.
Zhuang et al. (2017)
12 more

11 mentions without citation

Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds.
Mydy et al. (2021)
10 more