› 4zcu

X-ray diffraction
2.1Å resolution

Structure of calcium-bound regulatory domain of the human ATP-Mg/Pi carrier in the P2 form

Released:
DOI: 10.2210/pdb4zcu/pdb
PDB entry 4zcu coloured by chain, front view.
PDB entry 4zcu coloured by chain, side view.
PDB entry 4zcu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier.
Harborne SP, Ruprecht JJ, Kunji ER
Biochim Biophys Acta 1847 1245-53 (2015)
PMID: 26164100

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180072 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial adenyl nucleotide antiporter SLC25A24 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 165 amino acids
Theoretical weight: 18.87 KDa
Source organism: Homo sapiens
Expression system: Lactococcus lactis
UniProt:
  • Canonical: Q6NUK1 (Residues: 14-174; Coverage: 34%)
Gene names: APC1, MCSC1, SCAMC1, SLC25A24
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

3 bound ligands:
Ligand CA 12 x CA
Ligand SO4 8 x SO4
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P2
Unit cell:
a: 76.08Å b: 47.02Å c: 93.24Å
α: 90° β: 108.5° γ: 90°
R-values:
R R work R free
0.238 0.236 0.274
Expression system: Lactococcus lactis

Quick links

Citations

8 review citations

The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism.
Crichton et al. (2017)
7 more

6 mentions without citation

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.
Ruprecht et al. (2020)
5 more