› 4zcv

X-ray diffraction
2.8Å resolution

Structure of calcium-bound regulatory domain of the human ATP-Mg/Pi carrier in the P212121 form

Released:
DOI: 10.2210/pdb4zcv/pdb
PDB entry 4zcv coloured by chain, front view.
PDB entry 4zcv coloured by chain, side view.
PDB entry 4zcv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier.
Harborne SP, Ruprecht JJ, Kunji ER
Biochim Biophys Acta 1847 1245-53 (2015)
PMID: 26164100

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180072 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial adenyl nucleotide antiporter SLC25A24 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 165 amino acids
Theoretical weight: 18.87 KDa
Source organism: Homo sapiens
Expression system: Lactococcus lactis
UniProt:
  • Canonical: Q6NUK1 (Residues: 14-174; Coverage: 34%)
Gene names: APC1, MCSC1, SCAMC1, SLC25A24
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

3 bound ligands:
Ligand CA 13 x CA
Ligand SO4 6 x SO4
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 75.92Å b: 77.01Å c: 119.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.259
Expression system: Lactococcus lactis

Quick links

Citations

10 review citations

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.
Ruprecht et al. (2020)
9 more

4 mentions without citation

Calcium-regulated mitochondrial ATP-Mg/Pi carriers evolved from a fusion of an EF-hand regulatory domain with a mitochondrial ADP/ATP carrier-like domain.
Harborne et al. (2018)
3 more