› 4zec

X-ray diffraction
2.15Å resolution

PBP AccA from A. tumefaciens C58 in complex with agrocin 84

Released:
DOI: 10.2210/pdb4zec/pdb
Model geometry
Fit model/data
PDB entry 4zec coloured by chain, front view.
PDB entry 4zec coloured by chain, side view.
PDB entry 4zec coloured by chain, top view.
Source organism: Agrobacterium fabrum str. C58
Primary publication:
A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens.
El Sahili A, Li SZ, Lang J, Virus C, Planamente S, Ahmar M, Guimaraes BG, Aumont-Nicaise M, Vigouroux A, Soulère L, Reader J, Queneau Y, Faure D, Moréra S
OpenAccess logo PLoS Pathog 11 e1005071 (2015)
PMID: 26244338

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175996 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute-binding protein family 5 domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 490 amino acids
Theoretical weight: 55.96 KDa
Source organism: Agrobacterium fabrum str. C58
Expression system: Escherichia coli
UniProt:
  • Canonical: Q52012 (Residues: 32-521; Coverage: 99%)
Gene names: Atu6139, accA
Sequence domains: Bacterial extracellular solute-binding proteins, family 5 Middle
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand C84 1 x C84
Ligand PEG 1 x PEG
Ligand GOL 1 x GOL
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2221
Unit cell:
a: 77.18Å b: 114.17Å c: 111.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.239
Expression system: Escherichia coli

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Citations

4 review citations

Quorum Sensing and Quorum Quenching in Agrobacterium: A "Go/No Go System"?
Dessaux et al. (2018)
3 more

2 mentions without citation

Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases.
Travin et al. (2021)
1 more