› 4zgi

X-ray diffraction
2.7Å resolution

Structure of Truncated Human TIFA

Released:
DOI: 10.2210/pdb4zgi/pdb
PDB entry 4zgi coloured by chain, front view.
PDB entry 4zgi coloured by chain, side view.
PDB entry 4zgi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses.
Weng JH, Hsieh YC, Huang CC, Wei TY, Lim LH, Chen YH, Ho MR, Wang I, Huang KF, Chen CJ, Tsai MD
Biochemistry 54 6219-29 (2015)
PMID: 26389808

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188414 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TRAF-interacting protein with FHA domain-containing protein A Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96CG3 (Residues: 10-149; Coverage: 76%)
Gene names: T2BP, TIFA
Sequence domains: FHA domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 5 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P3221
Unit cell:
a: 39.009Å b: 39.009Å c: 178.459Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.226 0.264
Expression system: Escherichia coli

Quick links

Citations

3 review citations

FHA domains: Phosphopeptide binding and beyond.
Almawi et al. (2017)
2 more