› 4zi1

X-ray diffraction
2.1Å resolution

HUMAN ESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH KB095285 AND CIA12 COACTIVATOR PEPTIDE

Released:
DOI: 10.2210/pdb4zi1/pdb
PDB entry 4zi1 coloured by chain, front view.
PDB entry 4zi1 coloured by chain, side view.
PDB entry 4zi1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kauppi B, Bonn T

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187734 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Estrogen receptor beta Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 28.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92731 (Residues: 262-509; Coverage: 47%)
Gene names: ESR2, ESTRB, NR3A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 5 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9HCD5 (Residues: 341-352; Coverage: 2%)
Gene names: KIAA1637, NCOA5

Ligands and Environments

1 bound ligand:
Ligand KB0 1 x KB0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: I41
Unit cell:
a: 85.258Å b: 85.258Å c: 112.14Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.223
Expression systems:
  • Escherichia coli
  • Not provided

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