› 4zo2

X-ray diffraction
1.09Å resolution

AidC, a Dizinc Quorum-Quenching Lactonase

Released:
DOI: 10.2210/pdb4zo2/pdb
PDB entry 4zo2 coloured by chain, front view.
PDB entry 4zo2 coloured by chain, side view.
PDB entry 4zo2 coloured by chain, top view.
Source organism: Chryseobacterium sp. StRB126
Primary publication:
Structural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase with Atypical Selectivity.
Mascarenhas R, Thomas PW, Wu CX, Nocek BP, Hoang QQ, Liu D, Fast W
Biochemistry 54 4342-53 (2015)
PMID: 26115006

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125259 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metallo-beta-lactamase domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 294 amino acids
Theoretical weight: 33.1 KDa
Source organism: Chryseobacterium sp. StRB126
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: I7HB71 (Residues: 37-330; Coverage: 89%)
Gene names: CHSO_3121, aidC
Sequence domains: Metallo-beta-lactamase superfamily
Structure domains: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 53.257Å b: 97.88Å c: 110.871Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.131 0.131 0.162
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control.
Billot et al. (2020)
11 other articles

4 mentions without citation

Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity.
Lyagin et al. (2023)
3 more