› 5a0e

X-ray diffraction
1.25Å resolution

Crystal structure of cyclophilin D in complex with CsA analogue, JW47.

Released:
DOI: 10.2210/pdb5a0e/pdb
Model geometry
Fit model/data
PDB entry 5a0e coloured by chain, front view.
PDB entry 5a0e coloured by chain, side view.
PDB entry 5a0e coloured by chain, top view.
Source organisms:
Primary publication:
Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.
Warne J, Pryce G, Hill JM, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AW, Towers GJ, Coker AR, Duchen MR, Szabadkai G, Baker D, Selwood DL
OpenAccess logo J Biol Chem 291 4356-73 (2016)
PMID: 26679998

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151717 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase F, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 17.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30405 (Residues: 43-207; Coverage: 80%)
Gene names: CYP3, PPIF
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
JW47 Chains: C, E
Molecule details ›
Chains: C, E
Length: 11 amino acids
Theoretical weight: 1.38 KDa
Source organism: Cylindrocarpon lucidum
Expression system: Not provided

Ligands and Environments

No bound ligands
5 modified residues:
Ligand DAL 2 x DAL
Ligand MLE 8 x MLE
Ligand MVA 2 x MVA
Ligand ABA 2 x ABA
Ligand SAR 2 x SAR

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 38.12Å b: 69.51Å c: 109.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.1 0.098 0.131
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

17 review citations

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi et al. (2018)
16 more

2 mentions without citation

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.
Warne et al. (2016)
1 more