Function and Biology Details
Reactions catalysed:
(1a) S-adenosyl-L-methionine + G(5')pppAACA-[mRNA] = S-adenosyl-L-homocysteine + G(5')pppAmACA-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
(1a) (5')pppAACA-[mRNA] + (protein L)-L-histidine = diphosphate + (protein L)-L-histidyl-(5')phosphonato-AACA-[mRNA] + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Mononegavirales RNA-directed RNA polymerase catalytic domain
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- Mononegavirus L protein 2-O-ribose methyltransferase
- RNA-directed RNA polymerase L methyltransferase domain, rhabdovirus
- RNA-directed RNA polymerase L, C-terminal
- Mononegavirales mRNA-capping domain V
- RNA-directed RNA polymerase, rhabdovirus
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
RNA-directed RNA polymerase L (preferred)
PDBe Complex ID:
PDB-CPX-137108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-directed RNA polymerase L
Molecule details ›
Chain: A
Length: 2109 amino acids
Theoretical weight: 241.31 KDa
Source organism: Vesicular stomatitis virus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 2109 amino acids
Theoretical weight: 241.31 KDa
Source organism: Vesicular stomatitis virus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P03523 (Residues: 1-2109; Coverage: 100%)
Sequence domains:
