› 5a2e

X-ray diffraction
3.15Å resolution

Extracellular SRCR domains of human CD6

Released:
DOI: 10.2210/pdb5a2e/pdb
PDB entry 5a2e coloured by chain, front view.
PDB entry 5a2e coloured by chain, side view.
PDB entry 5a2e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.
Chappell PE, Garner LI, Yan J, Metcalfe C, Hatherley D, Johnson S, Robinson CV, Lea SM, Brown MH
Structure 23 1426-1436 (2015)
PMID: 26146185

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151675 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble CD6 Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 39.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P30203 (Residues: 1-364; Coverage: 53%)
Gene name: CD6
Sequence domains: Scavenger receptor cysteine-rich domain
Structure domains: SRCR-like domain

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P6322
Unit cell:
a: 161.48Å b: 161.48Å c: 93.85Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.253 0.283
Expression system: Cricetulus griseus

Quick links

Citations

6 review citations

SALSA-A dance on a slippery floor with changing partners.
Reichhardt et al. (2017)
5 more

8 mentions without citation

The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein.
Hiramoto et al. (2018)
7 more