› 5a2i

X-ray diffraction
1.88Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208481 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig heavy chain V-III region J606; Ig lambda-1 chain V region S43 Chain: H
Molecule details ›
Chain: H
Length: 244 amino acids
Theoretical weight: 25.74 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P01801 (Residues: 6-99, 102-115; Coverage: 94%)
  • Canonical: P01727 (Residues: 20-129; Coverage: 100%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
ANTIGEN TN, SER IS COVALENTLY BOUND TO GALNAC Chain: P
Molecule details ›
Chain: P
Length: 6 amino acids
Theoretical weight: 643 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand EDO 2 x EDO
Ligand A2G 1 x A2G
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 33.181Å b: 66.006Å c: 90.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.206 0.261
Expression systems:
  • Komagataella pastoris
  • Not provided

Quick links

Citations

11 review citations

Perspectives on Anti-Glycan Antibodies Gleaned from Development of a Community Resource Database.
Sterner et al. (2016)
10 more

2 mentions without citation

Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy.
Zhou et al. (2018)
1 more